Typhoid Vaccine Checker 2026

📋 Patient Factors

Indication / Risk Group

Patient Age

Pregnancy Status

Immune Status

Current Antibiotic Use

Antimalarial Prophylaxis

Previous Typhoid Vaccine & Type

Ongoing / Long-term Exposure

🗂️ Care Pathways

✈️ Traveller Eligibility ▼

Who should receive typhoid vaccine for travel?

Travellers aged ≥2 years to typhoid-endemic regions
Especially where food hygiene is suboptimal or water treatment unreliable
Travellers visiting friends and relatives (VFR) — higher risk group
Including immigrants returning to homelands

Age-based vaccine choice:

Under 2 yrs — vaccine NOT recommended (poorly immunogenic)
2–5 yrs — Typhim Vi (parenteral) only
≥6 yrs — Typhim Vi OR Vivotif Oral (3 or 4 doses)
≥16 yrs — Vivaxim (combo Hep A/typhoid) is an option

Travel advice to give:

Hand hygiene, food safety, boiled or bottled water only
Avoid: raw/undercooked shellfish, salads, cold meats, ice in drinks
Short day trips from quality accommodation can also be high risk

🔬 Occupational Groups ▼

Military personnel & laboratory workers:

Military personnel — recommend typhoid vaccine
Laboratory workers who routinely handle Salmonella Typhi — recommend typhoid vaccine

Options (both groups):

Parenteral Typhim Vi — 1 dose IM
Oral Vivotif — 3 doses (days 1, 3, 5) or 4 doses (add day 7) taken 1 hour before food

💡 4-dose oral course may provide better protection than 3 doses (ATAGI recommendation).

💉 Dosing & Administration ▼

Typhim Vi (parenteral):

0.5 mL IM — single dose, same volume for all ages
Registered: ≥2 years of age
Sponsor: Sanofi-Aventis Australia

Vivotif Oral (live attenuated):

Registered: ≥6 years of age
3-dose: 1 capsule on Day 1, 3, 5 — taken 1 hour before food, swallowed whole
4-dose: add Day 7 capsule (ATAGI recommended — better protection)
Sponsor: Biocelect Pty Ltd

Storage:

Both vaccines: +2°C to +8°C, do not freeze, protect from light
Oral vaccine: patient is responsible for transport from pharmacy to home — counsel carefully

🚫 Contraindications & Precautions ▼

Both vaccines — absolute contraindication:

Previous anaphylaxis to any typhoid vaccine or its components

Vivotif Oral — contraindicated in:

Children under 6 years (use Typhim Vi for ages 2–5)
Pregnancy (ATAGI — use Typhim Vi if travel is essential)
Immunocompromised patients incl. HIV (use Typhim Vi)
Current antibiotic use (use Typhim Vi, or delay oral vaccine)

Vivotif Oral — precautions:

Doxycycline / most antimalarials: finish oral typhoid course ≥3 days BEFORE starting
Mefloquine or Malarone: safe to co-administer (no interference)
Oral cholera vaccine: separate by ≥8 hours
Swallow capsules whole — do NOT chew or open (gastric acid destroys vaccine)

Typhim Vi — precaution in pregnancy:

Not routinely recommended in pregnancy/breastfeeding
May be given if travel to endemic region is unavoidable and benefit outweighs risk

🔄 Revaccination Schedule ▼

Revaccination is recommended for those with ongoing or long-term exposure to Salmonella Typhi (long-term travel, living in endemic region, occupational).

Parenteral (Typhim Vi):

Repeat dose every 3 years (applies from age ≥2 yrs)

Oral (Vivotif):

After a 3-dose course → revaccinate after 3 years
After a 4-dose course → revaccinate after 5 years
Only for age ≥6 years

⚠️ No prospective clinical trials in travellers — benefit is supported by epidemiological evidence. Vaccine effectiveness estimated at ~65% over 3 years in travellers.

⚗️ Co-administration with Other Vaccines ▼

Vivotif Oral:

✅ Can be given at same time as live parenteral vaccines (yellow fever, BCG, MMR)
✅ Safe with mefloquine or Malarone
⚠️ Oral cholera vaccine: separate by ≥8 hours (buffer affects gut transit)
🚫 Doxycycline and most other antimalarials: complete oral course ≥3 days before starting

Typhim Vi (parenteral):

✅ Can be given at any time before, after, or with other travel vaccines (e.g. oral cholera, yellow fever)
✅ No timing restrictions with other travel vaccines

Combination Hep A + Typhoid (Vivaxim):

Available for patients ≥16 years travelling to areas with risk of both diseases

📊 Vaccine Quick Reference

💊

Typhoid Vaccines Available in Australia

▼

Feature	Typhim Vi (parenteral)	Vivotif Oral
Type	Vi polysaccharide — inactivated	Live attenuated (Ty21a)
Route	IM injection, 0.5 mL	Oral capsule
Min. age	≥2 years	≥6 years
Doses	1 dose	3 (days 1,3,5) or 4 (add day 7)
Taken with food?	N/A	1 hour BEFORE food, swallow whole
Revaccination	Every 3 years (ongoing exposure)	3 yr after 3-dose; 5 yr after 4-dose
Pregnancy	Precaution — avoid unless essential	Contraindicated (ATAGI)
Immunocompromised	✅ Preferred option	🚫 Contraindicated
Antibiotics	✅ No interaction	🚫 Defer — antibiotics inactivate vaccine
Sponsor	Sanofi-Aventis Australia	Biocelect Pty Ltd
NIP funded?	❌ Not funded — private prescription

Source: Australian Immunisation Handbook (last reviewed 2 May 2025). For current product information visit the TGA website.

⚠️ Key Contraindications at a Glance

🚫

Anaphylaxis to any typhoid vaccineAbsolute contraindication to both vaccines.

🚫

Oral vaccine — under 6 yearsUse Typhim Vi for children aged 2–5 years.

🚫

Oral vaccine — immunocompromised / HIVUse Typhim Vi instead.

🚫

Oral vaccine — current antibioticsAntibiotics inactivate live vaccine — use Typhim Vi or defer.

🚫

Oral vaccine — pregnancy (ATAGI)Contraindicated. Use Typhim Vi if travel essential.

⚠️

Oral vaccine — doxycycline / antimalarialsComplete oral course ≥3 days before starting. Mefloquine/Malarone: OK to co-administer.

⚠️

Oral vaccine — oral cholera vaccineSeparate by ≥8 hours (buffer affects GI transit).

⚠️

Typhim Vi — pregnancy / breastfeedingNot routinely recommended. May be used if high benefit outweighs minimal risk.