⚠️ Clinical Decision Support Tool: This tool assists pharmacists in assessing hepatitis B vaccination eligibility per the Australian Immunisation Handbook (January 2026). It does not replace clinical judgement. Always verify vaccination history, check contraindications, and refer complex cases to a GP or infectious disease specialist.
Step 1 — Patient Profile
Step 2 — Risk Factor Screening
Reference — Serological Interpretation
Interpreting Hepatitis B Serological Test Results
| HBsAg | Anti-HBc | Anti-HBs | Interpretation |
|---|---|---|---|
| Negative | Negative | Negative | Susceptible — vaccinate |
| Negative | Negative | Positive | Immune from vaccination |
| Negative | Positive | Positive | Immune from natural infection |
| Positive | Positive (IgM+) | Negative | Acute infection |
| Positive | Positive (IgM−) | Negative | Chronic infection |
| Negative | Positive | Negative | Inconclusive — seek expert advice |
Reference — Standard Vaccine Schedules
Monovalent Hepatitis B Vaccines — Adolescents & Adults
| Vaccine / Formulation | Age | Dose (HBsAg) | Standard Schedule |
|---|---|---|---|
| Engerix-B Adult | 11–15 only | 20 μg | 2 doses: 0, 6 months |
| H-B-Vax II Adult | 11–15 only | 10 μg | 2 doses: 0, 6 months |
| Engerix-B Paediatric | <20 | 10 μg | 3 doses: 0, 1, 6 months |
| H-B-Vax II Paediatric | <20 | 5 μg | 3 doses: 0, 1, 6 months |
| Engerix-B Adult | ≥20 | 20 μg | 3 doses: 0, 1, 6 months |
| H-B-Vax II Adult | ≥20 | 10 μg | 3 doses: 0, 1, 6 months |
| H-B-Vax II Dialysis | ≥20 | 40 μg | 3 doses: 0, 1, 6 months |